Used For:

• Systemic & Mucocutaneous Fungal Infections

Contraindications:

• Hypersensitivity to fluconazole or other azole antifungalsConcomitant use with drugs like cisapride, terfenadine, astemizole, erythromycin, or pimozide (risk of QT prolongation)Severe liver diseasePregnancy (especially in high doses or long-term therapy) — may cause fetal harmLactation (passes into breast milk; occasional single-dose use may be acceptable under supervision)

Side Effects:

• Nausea, vomiting, abdominal painHeadache or dizzinessSkin rashDiarrheaMild elevation in liver enzymes

Precautions:

• Monitor liver function in patients on long-term or high-dose therapy.Use cautiously in renal impairment (dose adjustment needed if creatinine clearance <50 mL/min).Avoid concurrent use of drugs that prolong QT interval.Avoid long-term use without medical supervision.Pregnant or breastfeeding women: Use only if benefits outweigh risks.

Dietary Restrictions:

• Can be taken with or without food; food does not affect absorption.Avoid alcohol – increases risk of liver toxicity.Stay hydrated — helps with drug metabolism and reduces nausea.Avoid grapefruit juice (may interfere with metabolism, though minor effect).Do not take other antifungal or hepatotoxic drugs unless prescribed.