Used For:

• Treatment and prevention of fungal infections

Adult Dosage:

• Vaginal candidiasis: 150 mg single dose (may differ based on guidelines)Oral thrush: 100–200 mg on the first day, then 50–100 mg daily for 7–14 daysEsophageal candidiasis: 200 mg on day 1, then 100–200 mg daily for 14–21 daysSystemic fungal infections: 400–800 mg daily, depending on severity, under strict medical supervisionTake with or without food, preferably at the same time daily

Pack:

• 1s

Contraindications:

• Hypersensitivity to fluconazole or other azole antifungalsCo-administration with drugs that prolong QT interval (risk of arrhythmias)Severe hepatic impairment without monitoringPregnancy (especially first trimester) — only if benefits outweigh risksLactation — use with caution

Side Effects:

• Gastrointestinal: Nausea, vomiting, diarrhea, abdominal painCNS: Headache, dizzinessSkin: Rash, pruritusHepatic: Mild increase in liver enzymes

Precautions:

• Monitor liver function tests if therapy is prolonged (>2 weeks)Caution in patients with renal impairment; dose adjustment may be neededMonitor electrolytes and ECG if patient is on other QT-prolonging drugsAvoid self-medication — must be prescribed for confirmed fungal infectionInteractions: Fluconazole inhibits CYP3A4 and CYP2C9 → increases levels of warfarin, phenytoin, sulfonylureas, and some statins

Dietary Restrictions:

• No strict food restrictionsCan be taken with or without foodAvoid excessive alcohol — may increase liver stressMaintain hydration during therapyCheck with physician before taking herbal supplements (St. John’s Wort may reduce efficacy)